Part of the GLE 53's interior appeal can be attributed to the use of premium materials throughout the inside. As standard, black MB-Tex upholstery with red stitching complements the bolstered seats perfectly. However, for added luxury, there are ten other options available. Black Nappa leather upholstery can be had for $2,990, along with a Tartufo / Black combination, a Classic Red / Black combination and, new for 2022, Espresso Brown / Black and White / Black. Exclusive Black Nappa leather upholstery is available in the same shades as the regular Nappa selection for $4,550. If that doesn't do it for you, you can opt for Black Nappa leather with quilted stitching for $4,800, or you can clad your seats in Macchiato Beige Nappa leather for the same fee. Seatbelts are available in both black and red, and a Black Dinamica headliner can be had for $1,600. The AMG Performance steering wheel can be clad in Dinamica leather or a combination of that and Nappa leather. If that simply isn't enough, the MB-Tex top-stitched dash and door trim is optionally available for $350.

Two types of insert styles come standard, including Grey Linden wood and aluminum. Grey Oak or Walnut wood can be had for $160, while a metal weave will cost $600. For even more of your hard-earned dollars, designo Brown Linden "Flowing Lines" wood costs $850. But the ultimate option is the AMG Carbon Fiber that'll set you back $1,750.